Bone Marrow Cells Transplant in Septic Mice Modulates Systemic Inflammatory Response via Cell–Cell Contact
نویسندگان
چکیده
منابع مشابه
Reactive oxygen species mediate TNF-α-induced inflammatory response in bone marrow mesenchymal cells
Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α). In this study, we explored the mechanisms underlying the TNF-α-induced inflammatory ...
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پیوند مغز استخوان باید به مدت طولانی در بیمارستان بستری باشند، که این امر نیز موجب بروز برخی از عوارض روانی مانند: افسردگی، اضطراب، کج خلقی، ترس و ناامیدی در آنان خواهد شد. هرچند که برخورد صحیح کادر مراقبتی درمانی می تواند تا حد زیادی از این عوارض پیشگیری کند. در این مسیر تقویت اعتماد، اعتقاد، امید و تلاش برای سازگاری با مشکل ضرورت دارد. امروزه بسیاری از بیماریهای بدخیم به درمان با پیوند مغز اس...
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and multiple organ failure caused by infections correlate with high mortality. In infections with gram-negative bacteria, these systemic inflammatory responses are caused by lipopolysaccharide (LPS), the major component of the outer membrane. LPS triggers the production of various cytokines (TNF-a , IL-1b and IL-6 etc.), chemokines (IL-8 and monocyte chemoattractant protein 1 etc.), and biologi...
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Bone marrow-derived mesenchymal stem cells (BMDMSCs) appear to be important in repair of the chronic lung injury caused by bleomycin in mice. To determine effects of these BMDMSCs on an acute inflammatory response, we injected C57BL/6 mice intraperitoneally with 1 mg/kg endotoxin followed either by intravenous infusion of 5 x 10(5) BMDMSCs, the same number of lung fibroblasts, or an equal volum...
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Objective(s):Some evidence showed that calcitriol has an important role in regulating growth and differentiation of mesenchymal stem cells (MSCs). However, the interaction between mesenchymal stem cells and macrophage is not clear yet. The current study was done to investigate the in vitro effects of calcitriol on the interactions between bone marrow-derived MSCs and rat macrophages. Material...
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ژورنال
عنوان ژورنال: Shock
سال: 2019
ISSN: 1073-2322,1540-0514
DOI: 10.1097/shk.0000000000001151